首先就是长期安全性的考验。尽管不少专家认为自免CAR-T的长期风险可能低于肿瘤适应症，FDA的态度也较为积极，但这仍需数年甚至十余年的真实世界数据来最终验证。对于自免患者来说，免疫系统重置后，能否恢复正常功能？如对疫苗的正常应答能力。这需要严谨的上市后研究来回答。
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One season-ticket holder, who lives in the south of England, said on social media recently that they expect to miss seven or eight home games this season owing to the curse of the modern fixture schedule. The club are aware that this is not an isolated case. The problem is not new nor confined to Everton, who of course reap the benefits of every game that is switched for live television purposes and, let’s be frank, have not held as much appeal for broadcasters in recent years as they do this season. But in their inaugural campaign at a new home, Everton’s schedule has proved to be peculiar and, in turn, detrimental to fans adapting to new surroundings.